I am running a Roamerdrive in my 110 TD5 with 285/75R16 (32.8") and stock transfer case
No issues with drivability on the highway, on the flats I can quite comfortably cruise at 130kmh (80 mph) on flats. If I hit an incline, drop it to 4th and power through, or 3rd if I have to.
The Roamerdrive is a 28% increase in gearing, and can left engaged through all gears. I have on occasion forgotten to disengage after coming to a stop, and the resulting start reminds you quickly that it's engaged.
I have done a couple long trips with it, Vancouver to Moab, Vancouver Joshua Tree, couldn't imagine doing those trips without it.