IT could be really anywhere... Irvine / Orange County in general has a lot, same with around Santa Monica.
If you don't mind working in defense, Northrop Grumman's headquarters is in El Segundo, and Boeing has a massive facility in Seal Beach.
I can't speak to commutes, I will let someone else talk about that. I do know you want to avoid the 405 and 91 pretty much at all costs.
"It doesn't swoop, curve, or look like it's going fast when it's parked. It never looks like it's going fast. It doesn't go fast." - Richard Hammond, BBC Top Gear
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